Daily issue
Breakout Watch for Wednesday, October 28, 2026
71 US-listed large caps closed at a new 52-week high on Wednesday, October 28, 2026. The largest was Thermo Fisher Scientific Inc. (TMO) at $260.6B. Most represented industries: Medical - Diagnostics & Research (11), Biotechnology (5), Software - Application (5).
New 52-week highs
The ten largest by market cap. The one-month column compares the close with the close one month earlier.
| Symbol | Company | Close | vs a month ago | Industry |
|---|---|---|---|---|
| TMO | Thermo Fisher Scientific Inc.Medical - Diagnostics & Research | $704.69 | +3.8% | Medical - Diagnostics & Research |
| AMGN | Amgen Inc.Drug Manufacturers - General | $451.93 | +8.1% | Drug Manufacturers - General |
| TD | The Toronto-Dominion BankBanks - Diversified | $126.44 | +5.8% | Banks - Diversified |
| GILD | Gilead Sciences, Inc.Drug Manufacturers - General | $159.22 | +4.6% | Drug Manufacturers - General |
| BK | The Bank of New York Mellon CorporationInvestment - Banking & Investment Services | $141.91 | +6.1% | Investment - Banking & Investment Services |
| EMR | Emerson Electric Co.Industrial - Machinery | $167.71 | +5.2% | Industrial - Machinery |
| URI | United Rentals, Inc.Rental & Leasing Services | $1,174.95 | +12.6% | Rental & Leasing Services |
| TRGP | Targa Resources Corp.Oil & Gas Midstream | $306.09 | +10.3% | Oil & Gas Midstream |
| NDAQ | Nasdaq, Inc.Financial - Data & Stock Exchanges | $105.58 | +14.0% | Financial - Data & Stock Exchanges |
| A | Agilent Technologies, Inc.Medical - Diagnostics & Research | $181.56 | +3.6% | Medical - Diagnostics & Research |
Also at new highs (61 more): WAT, BIIB, MTD, LH, WST, RBRK, DGX, AER, RS, VTRS, MEDP, FTV, RVTY, CRL, HAS, EXEL, ICLR, CRBG, HALO, MANH, RRC, NTSK, GTLS, CAI, GTLB, HNGE, ETSY, CBC, PACS, QLYS, KNSA, ACA, CWAN, BLCO, CHE, AMRX, RUSHB, MANE, HAFN, TENB, CON, HTFL, LFST, NWE, KNTK, STNG, APLE, TRMD, GEF-B, CDNA, AVPT, ATKR, ALRM, ATRC, DBRG, DRH, IOSP, FTRE, PEB, SHO, AMPL
Setting up
43 large caps closed within 3% of a 52-week high that was set at least two weeks ago. The ten largest:
| Symbol | Company | Close | 52-week high | Below high | Industry |
|---|---|---|---|---|---|
| BLK | BlackRock, Inc.Asset Management | $1,158.03 | $1,187.17 | -2.5% | Asset Management |
| CB | Chubb LimitedInsurance - Property & Casualty | $355.72 | $365.91 | -2.8% | Insurance - Property & Casualty |
| BNS | The Bank of Nova ScotiaBanks - Diversified | $94.54 | $95.74 | -1.3% | Banks - Diversified |
| JCI | Johnson Controls International plcConstruction Materials | $157.42 | $160.41 | -1.9% | Construction Materials |
| MSI | Motorola Solutions, Inc.Communication Equipment | $483.41 | $494.85 | -2.3% | Communication Equipment |
| WBD | Warner Bros. Discovery, Inc.Entertainment | $30.95 | $30.99 | -0.1% | Entertainment |
| APD | Air Products and Chemicals, Inc.Chemicals - Specialty | $307.15 | $314.87 | -2.5% | Chemicals - Specialty |
| FAST | Fastenal CompanyIndustrial - Distribution | $51.45 | $52.92 | -2.8% | Industrial - Distribution |
| DVN | Devon Energy CorporationOil & Gas Exploration & Production | $51.29 | $52.71 | -2.7% | Oil & Gas Exploration & Production |
| EA | Electronic Arts Inc.Electronic Gaming & Multimedia | $209.70 | $210.20 | -0.2% | Electronic Gaming & Multimedia |
Also setting up (33 more): STRC, PBA, VRSN, IEX, HST, ALLE, EQH, CACI, BMNP, WBS, ESTC, GSAT, BIO, SLAB, SWX, TXNM, LGND, GBTG, CATY, ARX, OGN, LXP, SGRY, CBZ, ATAI, BWIN, PAYO, ADUS, DV, SEM, ABSI, VIR, STEL
Closing prices and market caps as of Wednesday, October 28, 2026. Most setups fail. For education only, not a recommendation.