Daily issue
Breakout Watch for Wednesday, October 21, 2026
15 US-listed large caps set a new 52-week high on Wednesday, October 21, 2026, ranked here by market cap. Most represented industries: Biotechnology (2), Medical - Diagnostics & Research (2), Communication Equipment (1).
New 52-week highs
| Symbol | Company | Industry | Market cap |
|---|---|---|---|
| TMO | Thermo Fisher Scientific Inc.Medical - Diagnostics & Research | Medical - Diagnostics & Research | Mega ($200B+) |
| ELV | Elevance Health Inc.Medical - Healthcare Plans | Medical - Healthcare Plans | Large ($10B to $200B) |
| MRNA | Moderna, Inc.Biotechnology | Biotechnology | Large ($10B to $200B) |
| HLT | Hilton Worldwide Holdings Inc.Travel Lodging | Travel Lodging | Large ($10B to $200B) |
| SN | SharkNinja, Inc.Furnishings, Fixtures & Appliances | Furnishings, Fixtures & Appliances | Large ($10B to $200B) |
| ZBRA | Zebra Technologies CorporationCommunication Equipment | Communication Equipment | Large ($10B to $200B) |
| MTCH | Match Group, Inc.Internet Content & Information | Internet Content & Information | Large ($10B to $200B) |
| TBBB | BBB Foods Inc.Discount Stores | Discount Stores | Mid ($2B to $10B) |
| MSM | MSC Industrial Direct Co., Inc.Industrial - Distribution | Industrial - Distribution | Mid ($2B to $10B) |
| IOVA | Iovance Biotherapeutics, Inc.Biotechnology | Biotechnology | Mid ($2B to $10B) |
| ITGR | Integer Holdings CorporationMedical - Devices | Medical - Devices | Mid ($2B to $10B) |
| CDNA | CareDx, IncMedical - Diagnostics & Research | Medical - Diagnostics & Research | Mid ($2B to $10B) |
| NHC | National HealthCare CorporationMedical - Care Facilities | Medical - Care Facilities | Mid ($2B to $10B) |
| GCT | GigaCloud Technology Inc.Software - Infrastructure | Software - Infrastructure | Mid ($2B to $10B) |
| PRCH | Porch Group, Inc.Insurance - Property & Casualty | Insurance - Property & Casualty | Mid ($2B to $10B) |
Archive note: names only. Market-cap buckets reflect the latest close (Tuesday, October 27, 2026), not that day's close. Prices shown as of the latest close. Most setups fail. For education only, not a recommendation.